Syracuse Game Saturday: Syracuse at Louisville prediction, odds, spread, line, over/under and betting info. for week 11

Syracuse football (Mandatory Credit: Mark Konezny-USA TODAY Sports)
Syracuse football (Mandatory Credit: Mark Konezny-USA TODAY Sports) /

Syracuse football enjoyed some much-needed rest during its recent bye week, and now the Orange heads back to Atlantic Coast Conference competition with a challenging road clash at Louisville on Saturday, Nov. 13, in an early afternoon battle from Cardinal Stadium.

After enduring three heart-breaking ACC losses in a row, all by just three points, the ‘Cuse is now on a two-game league winning streak, thanks to its miraculous victory at Virginia Tech and, more recently, a 21-6 success against long-time rival Boston College on the Hill.

Versus the Eagles, the Orange offense came out flat in the first half, but then the ‘Cuse managed three thrilling touchdowns in the third quarter to come away with the triumph. Running back Sean Tucker was tremendous, while the defense put the clamps down on Boston College.

Those two most recent results have propelled the Orange to above .500 in the 2021 season, and the ‘Cuse needs one win in its final three games to achieve post-season bowl eligibility. It won’t prove easy, though, as the Orange (5-4, 2-3) travels to Louisville, followed by a road trip to N.C. State and the home finale against Pittsburgh.

While the ‘Cuse was off this past weekend, the Cardinals (4-5, 2-4) most recently fell at home, 30-24, to Clemson. In the 2021 season, Louisville has defeated Eastern Kentucky, UCF, Florida State and Boston College.

The Cardinals’ setbacks during the present campaign are to the aforementioned Tigers, Ole Miss, Wake Forest, Virginia and N.C. State. A year ago, the Orange was pretty dreadful in a 30-0 drubbing at the hands of Louisville on the road.

Let’s hope that the ‘Cuse has a better showing this time around versus the Cardinals.

Syracuse vs. Louisville odds for week 11

Please check out WynnBET for the latest odds and betting information on the Orange at Louisville. As of Monday afternoon, the ‘Cuse was at +3.0 points, with the over/under set at 55.0 points.

Syracuse injury report vs. Louisville for week 11

For the latest updates on any potential developments on the injury front, I’d recommend taking a look at

Syracuse vs. Louisville prediction for week 11

I really think that the ‘Cuse can win this game at Louisville. The Cardinals aren’t a stellar team in 2021 by any stretch of the imagination, although they do have a dynamic quarterback in Malik Cunningham.

In emerging victorious over its last two ACC affairs, the Orange has built up some momentum, and I believe this will carry over when the ‘Cuse plays on the road against Louisville. I project the Orange to triumph here and reach bowl eligibility.

WynnBET Promo: Bet $1, Win $100 if any NFL or college football team scores. Claim offer now.

Syracuse next game and schedule

Following the Orange’s road date with Louisville, the ‘Cuse makes it two-consecutive ACC games outside of Central New York when the team travels to N.C. State on Saturday, Nov. 20.

Please visit for more information on the entire 2021 schedule.

What channel is the Syracuse game on for week 11

The Orange’s affair at Louisville is slated for a noon kick-off on Saturday, Nov. 13. Television coverage will get provided by ACC regional sports networks.

Syracuse vs. Louisville live stream

For Orange and Louisville fans who want to stream this game, you can check it out on fuboTV.

Next. Syracuse Football: Numerous bowl projections flowing in for the Orange. dark